Article
Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction.
Thorax - 1 Nov 2014
Lamontagne Maxime, Timens Wim, Hao Ke, Bossé Yohan, Laviolette Michel, Steiling Katrina, Campbell Joshua D, Couture Christian, Conti Massimo, Sherwood Karen, Hogg James C, Brandsma Corry-Anke, van den Berge Maarten, Sandford Andrew, Lam Stephen, Lenburg Marc E, Spira Avrum, Paré Peter D, Nickle David, Sin Don D, Postma Dirkje S
Abstract excerpt
BACKGROUND: COPD is a complex chronic disease with poorly understood pathogenesis. Integrative genomic approaches have the potential to elucidate the biological networks underlying COPD and lung function. We recently combined genome-wide genotyping and gene expression in 1111 human lung specimens to map expression quantitative trait loci (eQTL). OBJECTIVE: To determine causal associations between COPD and lung...
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