Article
Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease.
Human genomics - 15 Jan 2018
Morrow Jarrett D, Cho Michael H, Platig John, Zhou Xiaobo, DeMeo Dawn L, Qiu Weiliang, Celli Bartholome, Marchetti Nathaniel, Criner Gerard J, Bueno Raphael, Washko George R, Glass Kimberly, Quackenbush John, Silverman Edwin K, Hersh Craig P
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) significantly associated with chronic obstructive pulmonary disease (COPD). However, many genetic variants show suggestive evidence for association but do not meet the strict threshold for genome-wide significance. Integrative analysis of multiple omics datasets has the potential to identify novel genes...
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