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Article

New Distance-Based approach for Genome-Wide Association Studies.

IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000

Irigoien Itziar, Cormand Bru, Soler-Artigas Maria, Sanchez-Mora Cristina, Ramos-Quiroga Josep-Antoni, Arenas Concepcion

Abstract excerpt

With the rise of genome-wide association studies (GWAS), the analysis of typical GWAS data sets with thousands of single-nucleotide polymorphisms (SNPs) has become crucial in biomedicine research. Here, we propose a new method to identify SNPs related to disease in case-control studies. The method, based on genetic distances between individuals, takes into account the possible population substructure, and avoids...

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PMID: 34181548
DOI: 10.1109/TCBB.2021.3092812

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