Kullback-Leibler distance methods for detecting disease association with rare variants from sequencing data.

Abstract excerpt

Because next generation sequencing technology that can rapidly genotype most genetic variations genome, there is considerable interest in investigating the effects of rare variants on complex diseases. In this paper, we propose four Kullback-Leibler distance-based Tests (KLTs) for detecting genotypic differences between cases and controls. There are several features that set the proposed tests apart from existing...

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