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Article

Alanine substitution mutations in the DNA binding region of a global staphylococcal virulence regulator affect its structure, function, and stability.

International journal of biological macromolecules - 1 Jul 2018

Mandal Sukhendu, Ghosh Semanti, Sinha Debabrata, Seal Soham, Mahapa Avisek, Polley Soumitra, Saha Deeya, Sau Keya, Bagchi Angshuman, Sau Subrata

Abstract excerpt

SarA, a winged-helix DNA binding protein, is a global virulence regulator in Staphylococcus aureus. The putative DNA binding region of SarA is located between amino acid residues Leu 53 and Gln 97. Previous studies have demonstrated that residues at positions 84, 88, 89, and 90 are critical for its function. To precisely understand the roles of the DNA binding residues, we have investigated nine mutants of a...

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PMID: 29545063
DOI: 10.1016/j.ijbiomac.2018.03.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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