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Article

Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006

Liu Yingfang, Manna Adhar C, Pan Cheol-Ho, Kriksunov Irina A, Thiel Daniel J, Cheung Ambrose L, Zhang Gongyi

Abstract excerpt

The sarA locus in Staphylococcus aureus controls the expression of many virulence genes. The sarA regulatory molecule, SarA, is a 14.7-kDa protein (124 residues) that binds to the promoter region of target genes. Here we report the 2.6 A-resolution x-ray crystal structure of the dimeric winged helix SarA protein, which differs from the published SarA structure dramatically. In the crystal packing, multiple dimers...

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Identifiers

PMID: 16455801
DOI: 10.1073/pnas.0510439103
PMCID: PMC1413715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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