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Article

Staphylococcus aureus methicillin-resistance factor fmtA is regulated by the global regulator SarA.

PloS one - 1 Jan 2012

Zhao Yinglu, Verma Vidhu, Belcheva Antoaneta, Singh Atul, Fridman Michael, Golemi-Kotra Dasantila

Abstract excerpt

fmtA encodes a low-affinity penicillin binding protein in Staphylococcus aureus. It is part of the core cell wall stimulon and is involved in methicillin resistance in S. aureus. Here, we report that the transcription factor, SarA, a pleiotropic regulator of virulence genes in S. aureus, regulates the expression of fmtA. In vitro binding studies with purified SarA revealed that it binds to specific sites within...

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Deoxyribonuclease I
Gene Expression Regulation, Bacterial
Methicillin Resistance
Operon
Penicillin-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Multimerization

Protein Structure, Quaternary

Staphylococcus aureus

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Identifiers

PMID: 22952845
DOI: 10.1371/journal.pone.0043998
PMCID: PMC3431356

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Staphylococcus aureus methicillin-resistance factor fmtA is regulated by the global regulator SarA.PMID 22952845Read ↗

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