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Article

Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis.

The American journal of gastroenterology - 1 Oct 2018

Stickel Felix, Buch Stephan, Nischalke Hans Dieter, Weiss Karl Heinz, Gotthardt Daniel, Fischer Janett, Rosendahl Jonas, Marot Astrid, Elamly Mona, Casper Markus, Lammert Frank, McQuillin Andrew, Zopf Steffen, Spengler Ulrich, Marhenke Silke, Kirstein Martha M, Vogel Arndt, Eyer Florian, von Felden Johann, Wege Henning, Buch Thorsten, Schafmayer Clemens, Braun Felix, Deltenre Pierre, Berg Thomas, Morgan Marsha Y, Hampe Jochen

Abstract excerpt

OBJECTIVES: Variants in patatin-like phospholipase domain-containing 3 (PNPLA3; rs738409), transmembrane 6 superfamily member 2 (TM6SF2; rs58542926), and membrane bound O-acyltransferase domain containing 7 (MBOAT7; rs641738) are risk factors for the development of alcohol-related cirrhosis. Within this population, PNPLA3 rs738409 is also an established risk factor for the development of hepatocellular carcinoma...

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Acyltransferases
Aged
Carcinoma, Hepatocellular
Case-Control Studies
Disease Progression
Europe
Female
Genetic Predisposition to Disease
Genotype
Humans
Lipase
Liver
Liver Cirrhosis, Alcoholic
Liver Neoplasms
Male
Membrane Proteins
Middle Aged
Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 29535416
DOI: 10.1038/s41395-018-0041-8

Genes

PNPLA3
MBOAT7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis.PMID 29535416Read ↗

Genetic risk of alcohol-related liver cirrhosis: Associations of PNPLA3, TM6SF2, and a two-variant polygenic risk score.Semantic proximity Read ↗

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.Semantic proximity Read ↗

Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol MisusersSemantic proximity Read ↗

A study of genetic variants, genetic risk score and DNA methylation of PNPLA3 and TM6SF2 in alcohol liver cirrhosis.Semantic proximity Read ↗

Association and impact of SNPs in PNPLA3, TM6SF2 and MBOAT7 genes on prognosis factors of hepatocellular carcinoma with non-viral etiologySemantic proximity Read ↗

PNPLA3 risk allele is associated with risk of hepatocellular carcinoma but not decompensation in compensated cirrhosis.Semantic proximity Read ↗

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The impact of polymorphism in PNPLA3 and TM6SF2 genes on the susceptibility and survival of hepatitis C-related Hepatocellular carcinomaSemantic proximity Read ↗

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