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Article

A study of genetic variants, genetic risk score and DNA methylation of PNPLA3 and TM6SF2 in alcohol liver cirrhosis.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology - 1 Dec 2023

Shankarappa Bhagyalakshmi, Mahadevan Jayant, Murthy Pratima, Purushottam Meera, Viswanath Biju, Jain Sanjeev, Devarbhavi Harshad, Mysore V Ashok

Abstract excerpt

BACKGROUND: Genetic and epigenetic factors are associated with the development of alcohol-associated liver disease (AALD). The single nucleotide polymorphisms (SNPs), rs738409 in Patatin-like phospholipase domain-containing protein (PNPLA3) and rs58542926 in Transmembrane 6 Superfamily Member 2 (TM6SF2) are strongly associated with AALD in different global populations, Hence, we analyzed the genetic risk score...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Alcoholism
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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 37589914
DOI: 10.1007/s12664-023-01420-1

Genes

TM6SF2
PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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