Article
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.
Nature genetics - 1 Dec 2015
Buch Stephan, Stickel Felix, Trépo Eric, Way Michael, Herrmann Alexander, Nischalke Hans Dieter, Brosch Mario, Rosendahl Jonas, Berg Thomas, Ridinger Monika, Rietschel Marcella, McQuillin Andrew, Frank Josef, Kiefer Falk, Schreiber Stefan, Lieb Wolfgang, Soyka Michael, Semmo Nasser, Aigner Elmar, Datz Christian, Schmelz Renate, Brückner Stefan, Zeissig Sebastian, Stephan Anna-Magdalena, Wodarz Norbert, Devière Jacques, Clumeck Nicolas, Sarrazin Christoph, Lammert Frank, Gustot Thierry, Deltenre Pierre, Völzke Henry, Lerch Markus M, Mayerle Julia, Eyer Florian, Schafmayer Clemens, Cichon Sven, Nöthen Markus M, Nothnagel Michael, Ellinghaus David, Huse Klaus, Franke Andre, Zopf Steffen, Hellerbrand Claus, Moreno Christophe, Franchimont Denis, Morgan Marsha Y, Hampe Jochen
Abstract excerpt
Alcohol misuse is the leading cause of cirrhosis and the second most common indication for liver transplantation in the Western world. We performed a genome-wide association study for alcohol-related cirrhosis in individuals of European descent (712 cases and 1,426 controls) with subsequent validation in two independent European cohorts (1,148 cases and 922 controls). We identified variants in the MBOAT7 (P =...
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