Combined Effect of PNPLA3, TM6SF2, and HSD17B13 Variants on Risk of Cirrhosis and Hepatocellular Carcinoma in the General Population.

doi:10.1002/hep.31238

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Combined Effect of PNPLA3, TM6SF2, and HSD17B13 Variants on Risk of Cirrhosis and Hepatocellular Carcinoma in the General Population.

Hepatology (Baltimore, Md.) - 1 Sept 2020

Gellert-Kristensen Helene, Richardson Tom G, Davey Smith George, Nordestgaard Børge G, Tybjaerg-Hansen Anne, Stender Stefan

Abstract excerpt

BACKGROUND AND AIMS: We hypothesized that a genetic risk score (GRS) for fatty liver disease influences the risk of cirrhosis and hepatocellular carcinoma (HCC). Three genetic variants (patatin-like phospholipase domain-containing protein 3 [PNPLA3] p.I148M; transmembrane 6, superfamily member 2 [TM6SF2] p.E167K; and hydroxysteroid 17-beta dehydrogenase 13 [HSD17B13] rs72613567) were combined into a risk score,...

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PMID: 32190914
DOI: 10.1002/hep.31238

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