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Article

CRISPR/Cas9-mediated ASXL1 mutations in U937 cells disrupt myeloid differentiation.

International journal of oncology - 1 Apr 2018

Wu Zhi-Jie, Zhao Xin, Banaszak Lauren G, Gutierrez-Rodrigues Fernanda, Keyvanfar Keyvan, Gao Shou-Guo, Quinones Raffo Diego, Kajigaya Sachiko, Young Neal S

Abstract excerpt

Additional sex combs-like 1 (ASXL1) is a well‑known tumor suppressor gene and epigenetic modifier. ASXL1 mutations are frequent in myeloid malignances; these mutations are risk factors for the development of myelodysplasia and also appear as small clones during normal aging. ASXL1 appears to act as an epigenetic regulator of cell survival and myeloid differentiation; however, the molecular mechanisms underlying...

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Source

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Identifiers

PMID: 29532865
DOI: 10.3892/ijo.2018.4290
PMCID: PMC5843401

Genes

ASXL1

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Related research

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CRISPR/Cas9-mediated ASXL1 mutations in U937 cells disrupt myeloid differentiation.PMID 29532865Read ↗

[Role of ASXL1 mutation in myeloid malignancies].Semantic proximity Read ↗

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts.Semantic proximity Read ↗

The role of ASXL1 mutations and ASXL1 CircRNAs in cancer.Semantic proximity Read ↗

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of leukemiaSemantic proximity Read ↗

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations.Semantic proximity Read ↗

Generation and Characterization of Induced Pluripotent Stem Cells Carrying An ASXL1 Mutation.Semantic proximity Read ↗

Epigenetic regulation by ASXL1 in myeloid malignancies.Semantic proximity Read ↗

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice.Semantic proximity Read ↗

Role of ASXL1 in hematopoiesis and myeloid diseases.Semantic proximity Read ↗

Asxl1 deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors.Semantic proximity Read ↗

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.Semantic proximity Read ↗

Mutant ASXL1 Drives Transcriptional Activation and Repression in Human HematopoiesisSemantic proximity Read ↗

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