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POLARIS: Polygenic LD-adjusted risk score approach for set-based analysis of GWAS data.

Genetic epidemiology - 1 Jun 2018

Baker Emily, Schmidt Karl Michael, Sims Rebecca, O'Donovan Michael C, Williams Julie, Holmans Peter, Escott-Price Valentina, Consortium With The Gerad

Abstract excerpt

Polygenic risk scores (PRSs) are a method to summarize the additive trait variance captured by a set of SNPs, and can increase the power of set-based analyses by leveraging public genome-wide association study (GWAS) datasets. PRS aims to assess the genetic liability to some phenotype on the basis of polygenic risk for the same or different phenotype estimated from independent data. We propose the application of...

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Identifiers

PMID: 29532500
DOI: 10.1002/gepi.22117
PMCID: PMC6001515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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