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Article

PRSice: Polygenic Risk Score software.

Bioinformatics (Oxford, England) - 1 May 2015

Euesden Jack, Lewis Cathryn M, O'Reilly Paul F

Abstract excerpt

SUMMARY: A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS can also be used to establish the presence of a genetic signal in underpowered...

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Identifiers

PMID: 25550326
DOI: 10.1093/bioinformatics/btu848
PMCID: PMC4410663

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