Article
A new explained-variance based genetic risk score for predictive modeling of disease risk.
Statistical applications in genetics and molecular biology - 25 Sept 2012
Che Ronglin, Motsinger-Reif Alison A
Abstract excerpt
The goal of association mapping is to identify genetic variants that predict disease, and as the field of human genetics matures, the number of successful association studies is increasing. Many such studies have shown that for many diseases, risk is explained by a reasonably large number of variants that each explains a very small amount of disease risk. This is prompting the use of genetic risk scores in...
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