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Article

PolarMorphism enables discovery of shared genetic variants across multiple traits from GWAS summary statistics.

Bioinformatics (Oxford, England) - 24 Jun 2022

von Berg Joanna, Ten Dam Michelle, van der Laan Sander W, de Ridder Jeroen

Abstract excerpt

MOTIVATION: Pleiotropic SNPs are associated with multiple traits. Such SNPs can help pinpoint biological processes with an effect on multiple traits or point to a shared etiology between traits. We present PolarMorphism, a new method for the identification of pleiotropic SNPs from genome-wide association studies (GWAS) summary statistics. PolarMorphism can be readily applied to more than two traits or whole trait...

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PMID: 35758773
DOI: 10.1093/bioinformatics/btac228
PMCID: PMC9235478

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