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Statistical Methods for Disease Risk Prediction with Genotype Data.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Xia Xiaoxuan, Zhang Yexian, Wei Yingying, Wang Maggie Haitian

Abstract excerpt

Single-nucleotide polymorphism (SNP) is the basic unit to understand the heritability of complex traits. One attractive application of the susceptible SNPs is to construct prediction models for assessing disease risk. Here, we introduce prediction methods for human traits using SNPs data, including the polygenic risk score (PRS), linear mixed models (LMMs), penalized regressions, and methods for controlling...

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PMID: 36929084
DOI: 10.1007/978-1-0716-2986-4_15

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