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Article

Mutational Analysis of the Mitochondrial DNA Displacement-Loop Region in Human Retinoblastoma with Patient Outcome.

Pathology oncology research : POR - 1 Apr 2019

Singh Lata, Saini Neeru, Pushker Neelam, Bakhshi Sameer, Sen Seema, Nag Tapas C, Kashyap Seema

Abstract excerpt

Alteration in mitochondrial DNA plays an important role in the development and progression of cancer. The Displacement Loop (D-loop) region of mitochondrial DNA (mtDNA) is the regulatory region for its replication and transcription. Therefore, we aimed to characterize mutations in the D-loop region of mitochondrial DNA along with the morphological changes and analyzed their impact on survival in retinoblastoma...

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PMID: 29532407
DOI: 10.1007/s12253-018-0391-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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