Article
Mitochondrial subversion in cancer.
Cancer prevention research (Philadelphia, Pa.) - 1 May 2011
Chatterjee Aditi, Dasgupta Santanu, Sidransky David
Abstract excerpt
Mitochondria control essential cellular activities including generation of ATP via oxidative phosphorylation. Mitochondrial DNA (mtDNA) mutations in the regulatory D-loop region and somatic mtDNA mutations are common in primary human cancers. The biological impact of a given mutation may vary, depending on the nature of the mutation and the proportion of mutant mtDNAs carried by the cell. Identification of mtDNA...
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