Article
Collagen XVIII and LOXL-4 polymorphisms in women with and without advanced pelvic organ prolapse.
International urogynecology journal - 1 Jun 2018
Dos Santos Renata G M, Pepicelli Fernanda C A, Batista Nilce C, de Carvalho Cristina V, Bortolini Maria A T, Castro Rodrigo A
Abstract excerpt
INTRODUCTION AND HYPOTHESIS: We verified the presence of single nucleotide polymorphisms (SNP) rs2236479 of the collagen 18 (COL18A1) and rs2862296 of the lysyl oxidase-like 4 (LOXL-4) genes and the association with pelvic organ prolapse (POP) in Brazilian women and determined risk factors for POP development. METHODS: We assessed 532 postmenopausal women divided into POP (stages III and IV) and control (stages 0...
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