Article
Evaluation of demographic, clinical characteristics, and genetic polymorphism as risk factors for pelvic organ prolapse in Brazilian women.
Neurourology and urodynamics - 1 Sept 2011
Martins Karina de Falco, de Jármy-DiBella Zsuzsanna Ilona Katalin, da Fonseca Andrea Moura Rodrigues Maciel, Castro Rodrigo Aquino, da Silva Ismael Dale Cotrim Guerreiro, Girão Manoel João Batista Castello, Sartori Marair Gracio Ferreira
Abstract excerpt
OBJECTIVE: Verify the association between genital prolapse, other risk factors and a polymorphism in exon 31 of the collagen III-a1 gene (COL3A1). SETTING: The etiology of genital prolapse is multifactorial, and genetic defects have been proposed. Also, there is evidence that changes in collagen may be responsible for defects in pelvic floor support. The exon 31 polymorphism results in structural changes in the...
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