Article
COL3A1 2209G>A is a predictor of pelvic organ prolapse.
International urogynecology journal and pelvic floor dysfunction - 1 Sept 2009
Kluivers Kirsten B, Dijkstra Jeroen R, Hendriks Jan C M, Lince Sabrina L, Vierhout Mark E, van Kempen Léon C L
Abstract excerpt
INTRODUCTION AND HYPOTHESIS: A familial tendency has been demonstrated in the etiology of pelvic organ prolapse (POP), but the specific genetic defects have not been identified. Type III collagen is an important factor in the repair of connective tissue, and gene polymorphisms may impair the tensile strength. We hypothesized that polymorphisms in the alpha I chain of the type III collagen protein-encoding gene...
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