Article
Cockayne's Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation.
Molecular cell - 21 Dec 2017
Epanchintsev Alexey, Costanzo Federico, Rauschendorf Marc-Alexander, Caputo Manuela, Ye Tao, Donnio Lise-Marie, Proietti-de-Santis Luca, Coin Frederic, Laugel Vincent, Egly Jean-Marc
Abstract excerpt
Cockayne syndrome (CS) is caused by mutations in CSA and CSB. The CSA and CSB proteins have been linked to both promoting transcription-coupled repair and restoring transcription following DNA damage. We show that UV stress arrests transcription of approximately 70% of genes in CSA- or CSB-deficient cells due to the constitutive presence of ATF3 at CRE/ATF sites. We found that CSB, CSA/DDB1/CUL4A, and MDM2 were...
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