B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity.

doi:10.1158/1078-0432.CCR-17-2852

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Article

B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2018

Yonesaka Kimio, Haratani Koji, Takamura Shiki, Sakai Hitomi, Kato Ryoji, Takegawa Naoki, Takahama Takayuki, Tanaka Kaoru, Hayashi Hidetoshi, Takeda Masayuki, Kato Sigeki, Maenishi Osamu, Sakai Kazuko, Chiba Yasutaka, Okabe Takafumi, Kudo Keita, Hasegawa Yoshikazu, Kaneda Hiroyasu, Yamato Michiko, Hirotani Kenji, Miyazawa Masaaki, Nishio Kazuto, Nakagawa Kazuhiko

Abstract excerpt

Purpose: Anti-programmed-death-1 (PD-1) immunotherapy improves survival in non-small cell lung cancer (NSCLC), but some cases are refractory to treatment, thereby requiring alternative strategies. B7-H3, an immune-checkpoint molecule, is expressed in various malignancies. To our knowledge, this study is the first to evaluate B7-H3 expression in NSCLCs treated with anti-PD-1 therapy and the therapeutic potential...

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Identifiers

PMID: 29530936
DOI: 10.1158/1078-0432.CCR-17-2852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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