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Article

HHLA2, a New Immune Checkpoint Member of the B7 Family, Is Widely Expressed in Human Lung Cancer and Associated with EGFR Mutational Status.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2017

Cheng Haiying, Janakiram Murali, Borczuk Alain, Lin Juan, Qiu Wanglong, Liu Huijie, Chinai Jordan M, Halmos Balazs, Perez-Soler Roman, Zang Xingxing

Abstract excerpt

PURPOSE: Immunotherapy with antibodies against B7/CD28 family members, including PD-1, PD-L1, and CTLA-4 has shifted the treatment paradigm for non-small cell lung carcinoma (NSCLC) with improved clinical outcome. HHLA2 is a newly discovered member of the family. By regulating T-cell function, HHLA2 could contribute to tumor immune suppression and thus be a novel target for cancer immunotherapy. There is limited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27553831
DOI: 10.1158/1078-0432.CCR-15-3071
PMCID: PMC5290088

Genes

HHLA2
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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