Article
Dysregulation of TFH-B-TRM lymphocyte cooperation is associated with unfavorable anti-PD-1 responses in EGFR-mutant lung cancer.
Nature communications - 18 Oct 2021
Cho Jae-Won, Park Seyeon, Kim Gamin, Han Heonjong, Shim Hyo Sup, Shin Sunhye, Bae Yong-Soo, Park Seong Yong, Ha Sang-Jun, Lee Insuk, Kim Hye Ryun
Abstract excerpt
Patients with non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations exhibit an unfavorable response to PD-1 inhibitor through unclear mechanisms. Hypothesizing that EGFR mutations alter tumor-immune interactions, we compare tumor-infiltrating lymphocytes between EGFR mutant (EGFR-MT) and wild type (EGFR-WT) tumors through single-cell transcriptomic analysis. We find that B...
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