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A novel subset of B7-H3<sup>+</sup>CD14<sup>+</sup>HLA-DR<sup>−/low</sup>myeloid-derived suppressor cells are associated with progression of human NSCLC

1 Feb 2015

Abstract excerpt

Myeloid-derived suppressor cells (MDSC) potently inhibit antitumor immune responses, and thereby promoti tumor progression and metastasis. However, the nature of human tumor-infiltrating MDSC remains poorly characterized. Here, we find B7-H3 is exclusively expressed on a subset of intratumoral CD14+HLA-DR−/low MDSC but absent from adjacent normal lung tissues of patients with non-small cell lung carcinoma...

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Chemokine receptors and signaling
Immune cells in cancer
Inflammation biomarkers and pathways

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25949876
DOI: 10.4161/2162402x.2014.977164

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