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Article

Wide Expression and Significance of Alternative Immune Checkpoint Molecules, B7x and HHLA2, in PD-L1-Negative Human Lung Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2018

Cheng Haiying, Borczuk Alain, Janakiram Murali, Ren Xiaoxin, Lin Juan, Assal Amer, Halmos Balazs, Perez-Soler Roman, Zang Xingxing

Abstract excerpt

Purpose: Immunotherapy targeting the PD-1/PD-L1 pathway has changed the treatment landscape of non-small cell lung carcinoma (NSCLC). We demonstrated that HHLA2, a newly identified immune inhibitory molecule, was widely expressed in NSCLC. We now compared the expression and function of PD-L1 with alternative immune checkpoints, B7x and HHLA2.Experimental Design: Expression was examined in tissue microarrays...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29374053
DOI: 10.1158/1078-0432.CCR-17-2924
PMCID: PMC5899616

Genes

HHLA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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