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Article

Multidimensional Analysis of B7 Homolog 3 RNA Expression in Small Cell Lung Cancer Molecular Subtypes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Aug 2025

Gay Carl M, Owonikoko Taofeek K, Byers Lauren A, Choudhury Noura J, Ahmed Sajid, Cain Zachary, Qian Xiaozhong, Brentnall Matthew, Heeke Simon, Poi Ming, Wu Sharon, Rudin Charles M

Abstract excerpt

PURPOSE: B7 homolog 3 (B7-H3) is a promising target for antibody-drug conjugates, with ifinatamab deruxtecan demonstrating an objective response rate of 54.8% in previously treated extensive-stage small cell lung cancer (SCLC). This analysis aimed to characterize B7-H3 RNA expression with reference to SCLC molecular subtypes (SCLC-A, SCLC-N, SCLC-P, and SCLC-I) and immune-related parameters. EXPERIMENTAL DESIGN:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers, Tumor

Share to Gene Expression Regulation, Neoplastic

Share to Intracellular Signaling Peptides and Proteins

Share to Lung Neoplasms

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Source

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Identifiers

PMID: 40553459
DOI: 10.1158/1078-0432.CCR-24-3981
PMCID: PMC12351277

Genes

DLL3
SEZ6
CD86
HAVCR2
PDCD1LG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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