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Article

Non-small cell lung cancer induces an immunosuppressive phenotype of dendritic cells in tumor microenvironment by upregulating B7-H3.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2011

Schneider Thomas, Hoffmann Hans, Dienemann Hendrik, Schnabel Philipp A, Enk Alexander H, Ring Sabine, Mahnke Karsten

Abstract excerpt

INTRODUCTION: Tumors may shift the phenotype and function of dendritic cells (DC) toward the induction of tolerance. In the status of full maturity, DC express a multitude of T cell costimulatory molecules enabling them to induce immune reactions, whereas nonactivated resident DC lack these T cell stimulating capacities. Therefore, we investigated the changes in DC phenotype and expression of B7-H molecules...

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Identifiers

PMID: 21597388
DOI: 10.1097/JTO.0b013e31821c421d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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