Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice.

doi:10.1053/j.gastro.2016.08.024

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Article

Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice.

Gastroenterology - 1 Dec 2016

David Bruna Araujo, Rezende Rafael Machado, Antunes Maísa Mota, Santos Mônica Morais, Freitas Lopes Maria Alice, Diniz Ariane Barros, Sousa Pereira Rafaela Vaz, Marchesi Sarah Cozzer, Alvarenga Débora Moreira, Nakagaki Brenda Naemi, Araújo Alan Moreira, Dos Reis Daniela Silva, Rocha Renata Monti, Marques Pedro Elias, Lee Woo-Yong, Deniset Justin, Liew Pei Xiong, Rubino Stephen, Cox Laura, Pinho Vanessa, Cunha Thiago Mattar, Fernandes Gabriel Rocha, Oliveira André Gustavo, Teixeira Mauro Martins, Kubes Paul, Menezes Gustavo Batista

Abstract excerpt

BACKGROUND & AIMS: Resident macrophages are derived from yolk sac precursors and seed the liver during embryogenesis. Native cells may be replaced by bone marrow precursors during extensive injuries, irradiation, and infections. We investigated the liver populations of myeloid immune cells and their location, as well as the dynamics of phagocyte repopulation after full depletion. The effects on liver function due...

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PMID: 27569723
DOI: 10.1053/j.gastro.2016.08.024

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