Article
Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis.
Circulation - 2 Mar 2021
Trinder Mark, Wang Yanan, Madsen Christian M, Ponomarev Tatjana, Bohunek Lubos, Daisely Brendan A, Julia Kong HyeJin, Blauw Lisanne L, Nordestgaard Børge G, Tybjærg-Hansen Anne, Wurfel Mark M, Russell James A, Walley Keith R, Rensen Patrick C N, Boyd John H, Brunham Liam R
Abstract excerpt
BACKGROUND: The high-density lipoprotein hypothesis of atherosclerosis has been challenged by clinical trials of cholesteryl ester transfer protein (CETP) inhibitors, which failed to show significant reductions in cardiovascular events. Plasma levels of high-density lipoprotein cholesterol (HDL-C) decline drastically during sepsis, and this phenomenon is explained, in part, by the activity of CETP, a major...
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