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Article

Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD.

JCI insight - 8 Mar 2018

Li Ao, Xu Yuchen, Fan Song, Meng Jialin, Shen Xufeng, Xiao Qian, Li Yuan, Zhang Li, Zhang Xiansheng, Wu Guanqing, Liang Chaozhao, Wu Dianqing

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) can be caused by mutations in the PKD1 or PKD2 genes. The PKD1 gene product is a Wnt cell-surface receptor. We previously showed that a lack of the PKD2 gene product, PC2, increases β-catenin signaling in mouse embryonic fibroblasts, kidney renal epithelia, and isolated renal collecting duct cells. However, it remains unclear whether β-catenin signaling plays a...

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Source

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Identifiers

PMID: 29515026
DOI: 10.1172/jci.insight.95874
PMCID: PMC5922276

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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