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Article

Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice.

The American journal of pathology - 1 Oct 2015

Li Ao, Tian Xin, Zhang Xiaoli, Huang Shunwei, Ma Yujie, Wu Dianqing, Moeckel Gilbert, Somlo Stefan, Wu Guanqing

Abstract excerpt

Although much is known about the molecular genetic mechanisms of autosomal-dominant polycystic kidney disease (ADPKD), few effective treatment is currently available. Here, we explore the in vivo effects of causal gene replacement in orthologous gene models of ADPKD in mice. Wild-type mice with human PKD2 transgene (PKD2(tg)) overexpressed polycystin (PC)-2 in several tissues, including the kidney and liver, and...

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Identifiers

PMID: 26435415
DOI: 10.1016/j.ajpath.2015.06.014
PMCID: PMC4607765

Genes

PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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