Article
T-cell factor/β-catenin activity is suppressed in two different models of autosomal dominant polycystic kidney disease.
Kidney international - 1 Jul 2011
Miller Michelle M, Iglesias Diana M, Zhang Zhao, Corsini Rachel, Chu LeeLee, Murawski Inga, Gupta Indra, Somlo Stefan, Germino Gregory G, Goodyer Paul R
Abstract excerpt
During murine kidney development, canonical WNT signaling is highly active in tubules until about embryonic days E16-E18. At this time, β-catenin transcriptional activity is progressively restricted to the nephrogenic zone. The cilial protein genes PKD1 and PKD2 are known to be mutated in autosomal dominant polycystic kidney disease (ADPKD), and previous studies proposed that these mutations could lead to a...
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