Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions.

doi:10.18632/oncotarget.14366

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Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions.

Oncotarget - 14 Feb 2017

Gao Boning, Huang Chunxian, Kernstine Kemp, Pelekanou Vasiliki, Kluger Yuval, Jiang Tingting, Peters-Hall Jennifer R, Coquelin Melissa, Girard Luc, Zhang Wei, Huffman Kenneth, Oliver Dwight, Kinose Fumi, Haura Eric, Teer Jamie K, Rix Uwe, Le Anh T, Aisner Dara L, Varella-Garcia Marileila, Doebele Robert C, Covington Kyle R, Hampton Oliver A, Doddapaneni Harsha V, Jayaseelan Joy C, Hu Jianhong, Wheeler David A, Shay Jerry W, Rimm David L, Gazdar Adi, Minna John D

Abstract excerpt

The "conditionally reprogrammed cells" (CRC) method, using a Rho kinase inhibitor and irradiated mouse fibroblast cells has been described for the efficient growth of cells from malignant and non-malignant samples from primary tumor and non-malignant sites. Using the CRC method, four institutions independently cultured tumor tissues from 48 non-small cell lung cancers (NSCLC, mostly from primary resected tumors)...

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PMID: 28052041
DOI: 10.18632/oncotarget.14366
PMCID: PMC5355251

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