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Article

Genomic comparison of early-passage conditionally reprogrammed breast cancer cells to their corresponding primary tumors.

PloS one - 1 Jan 2017

Mahajan Akanksha S, Sugita Bruna M, Duttargi Anju N, Saenz Francisco, Krawczyk Ewa, McCutcheon Justine N, Fonseca Aline S, Kallakury Bhaskar, Pohlmann Paula, Gusev Yuriy, Cavalli Luciane R

Abstract excerpt

Conditionally reprogrammed cells (CRCs) are epithelial cells that are directly isolated from patients' specimens and propagated in vitro with feeder cells and a Rho kinase inhibitor. A number of these cells have been generated from biopsies of breast cancer patients, including ductal carcinoma in situ and invasive carcinomas. The characterization of their genomic signatures is essential to determine their ability...

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Identifiers

PMID: 29049316
DOI: 10.1371/journal.pone.0186190
PMCID: PMC5648156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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