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Article

Remdesivir for the treatment of Covid-19: the value of biochemical studies

12 May 2021

Abstract excerpt

The nucleotide analogue prodrug remdesivir remains the only FDA-approved antiviral small molecule for the treatment of infection with SARS-CoV-2. Biochemical studies revealed that the active form of the drug targets the viral RNA-dependent RNA polymerase and causes delayed chain-termination. Delayed chain-termination is incomplete, but the continuation of RNA synthesis enables a partial escape from viral...

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PMID: 34052732
DOI: 10.1016/j.coviro.2021.04.014

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