Article

Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir

2022-01-29

Abstract excerpt

The nucleoside analog remdesivir (RDV) is an FDA-approved antiviral for the treatment of SARS- CoV-2 infections, and as such it is critical to understand potential genetic determinants and barriers to RDV resistance. In this study, SARS-CoV-2 was subjected to 13 passages in cell culture with increasing concentrations of GS-441524, the parent nucleoside of RDV. At passage 13 the RDV resistance of the lineages range...

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Literature Corpus work: 8eb8738b-b943-57b4-b01e-989dfca5b18c
DOI: 10.1101/2022.01.25.477724

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