Article
A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance.
mBio - 31 Aug 2023
Grimes Samantha L, Choi Young J, Banerjee Anoosha, Small Gabriel, Anderson-Daniels Jordan, Gribble Jennifer, Pruijssers Andrea J, Agostini Maria L, Abu-Shmais Alexandra, Lu Xiaotao, Darst Seth A, Campbell Elizabeth, Denison Mark R
Abstract excerpt
Coronaviruses (CoVs) encode nonstructural proteins 1-16 (nsps 1-16) which form replicase complexes that mediate viral RNA synthesis. Remdesivir (RDV) is an adenosine nucleoside analog antiviral that inhibits CoV RNA synthesis. RDV resistance mutations have been reported only in the nonstructural protein 12 RNA-dependent RNA polymerase (nsp12-RdRp). We here show that a substitution mutation in the nsp13-helicase...
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