Article
Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains.
Thorax - 1 Feb 2022
Ghosh Auyon J, Saferali Aabida, Lee Sool, Chase Robert, Moll Matthew, Morrow Jarrett, Yun Jeong, Castaldi Peter J, Hersh Craig P
Abstract excerpt
RATIONALE: COPD can be assessed using multidimensional grading systems with components from three domains: pulmonary function tests, symptoms and systemic features. Clinically, measures may be used interchangeably, though it is not known if they share similar pathobiology. OBJECTIVE: To use RNA sequencing (RNA-seq) to determine if there is an overlap in the underlying biological mechanisms and consequences...
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