Article
Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility.
Human genomics - 7 Jan 2016
Bruse Shannon, Moreau Michael, Bromberg Yana, Jang Jun-Ho, Wang Nan, Ha Hongseok, Picchi Maria, Lin Yong, Langley Raymond J, Qualls Clifford, Klensney-Tait Julia, Zabner Joseph, Leng Shuguang, Mao Jenny, Belinsky Steven A, Xing Jinchuan, Nyunoya Toru
Abstract excerpt
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by an irreversible airflow limitation in response to inhalation of noxious stimuli, such as cigarette smoke. However, only 15-20 % smokers manifest COPD, suggesting a role for genetic predisposition. Although genome-wide association studies have identified common genetic variants that are associated with susceptibility to COPD, effect sizes...
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