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Article

Siglec genes confer resistance to systemic lupus erythematosus in humans and mice.

Cellular & molecular immunology - 1 Feb 2019

Flores Rhonda, Zhang Peng, Wu Wei, Wang Xu, Ye Peiying, Zheng Pan, Liu Yang

Abstract excerpt

A recent meta-analysis revealed the contribution of the SIGLEC6 locus to the risk of developing systemic lupus erythematosus (SLE). However, no specific Siglec (sialic acid-binding immunoglobulin-like lectin) genes (Siglecs) have been implicated in the pathogenesis of SLE. Here, we performed in silico analysis of the function of three major protective alleles in the locus and found that these alleles were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29503442
DOI: 10.1038/cmi.2017.160
PMCID: PMC6355849

Genes

SIGLEC12
SIGLEC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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