Article
Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus.
Disease models & mechanisms - 1 Sept 2014
Crampton Steve P, Morawski Peter A, Bolland Silvia
Abstract excerpt
Systemic lupus erythematosus (SLE) represents a challenging autoimmune disease from a clinical perspective because of its varied forms of presentation. Although broad-spectrum steroids remain the standard treatment for SLE, they have many side effects and only provide temporary relief from the symptoms of the disease. Thus, gaining a deeper understanding of the genetic traits and biological pathways that confer...
Topics
- Animals
- Disease Models, Animal
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Lupus Erythematosus, Systemic
- Mice
- Mice, Inbred C57BL