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Article

Gene-function studies in systemic lupus erythematosus.

Nature reviews. Rheumatology - 1 Aug 2013

Crispín José C, Hedrich Christian M, Tsokos George C

Abstract excerpt

The aetiology of systemic lupus erythematosus (SLE) is complex and is known to involve both genetic and environmental factors. In a small number of patients, single-gene defects can lead to the development of SLE. Such genes include those encoding early components of the complement cascade and the 3'-5' DNA exonuclease TREX1. In addition, genome-wide association studies have identified single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23732569
DOI: 10.1038/nrrheum.2013.78

Genes

ITGAM
SIAE
TREX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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