Article
Preface and overview: genetics of SLE; a sine qua non for identification.
International reviews of immunology - 1 Jan 2000
Shirai T, Hirose S
Abstract excerpt
Clinical manifestations of systemic lupus erythematosus (SLE) are extremely diverse and variable, mainly because SLE is a multi-factorial disease. Variable combinations of contributing genes at multiple loci in individual patients probably result in diverse disease phenotypes. Genes that predispose to SLE are undoubtedly related to key events in pathogenesis, and may involve a variety of genes in immune system....
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