Article
Mapping ligand binding pockets in chloride ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid.
British journal of pharmacology - 1 May 2018
Altamura C, Mangiatordi G F, Nicolotti O, Sahbani D, Farinato A, Leonetti F, Carratù M R, Conte D, Desaphy J-F, Imbrici P
Abstract excerpt
BACKGROUND AND PURPOSE: Although chloride channels are involved in several physiological processes and acquired diseases, the availability of compounds selectively targeting CLC proteins is limited. ClC-1 channels are responsible for sarcolemma repolarization after an action potential in skeletal muscle and have been associated with myotonia congenita and myotonic dystrophy as well as with other muscular...
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