Article

Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore module

2023-04-13

Abstract excerpt

The sodium (Na + ) leak channel (NALCN) is a member of the four-domain voltage-gated cation channel family that includes the prototypical voltage-gated sodium and calcium channels (Na V s and Ca V s, respectively). Unlike Na V s and Ca V s, which have four lateral fenestrations that serve as routes for lipophilic compounds to enter the central cavity to modulate channel function, NALCN has bulky residues (W31...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40a2a70e-122e-557f-a63d-38be57f38724
DOI: 10.1101/2023.04.12.536537

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore moduleDOI 10.1101/2023.04.12.536537Read

New insights into the therapeutic inhibition of voltage-gated sodium channels.Semantic proximity Read

Diminazene Is a Slow Pore Blocker of Acid-Sensing Ion Channel 1a (ASIC1a).Semantic proximity Read

The sodium leak channel complex is modulated by voltage and extracellular calciumSemantic proximity Read

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting.Semantic proximity Read

Access and binding of local anesthetics in the closed sodium channel.Semantic proximity Read

A drug pocket at the lipid bilayer-potassium channel interface.Semantic proximity Read

From molecule to malady.Semantic proximity Read

Niclosamide potentiates TMEM16A and induces vasoconstrictionSemantic proximity Read

Defining the Polycystin Pharmacophore Through HTS & Computational BiophysicsSemantic proximity Read

Recent advances in treatment of epilepsy-related sodium channelopathiesSemantic proximity Read

Sodium channels, inherited epilepsy, and antiepileptic drugs.Semantic proximity Read

A lower X-gate in TASK channels traps inhibitors within the vestibule.Semantic proximity Read