Article
A designed inhibitor of a CLC antiporter blocks function through a unique binding mode.
Chemistry & biology - 21 Nov 2012
Howery Andrew E, Elvington Shelley, Abraham Sherwin J, Choi Kee-Hyun, Dworschak-Simpson Sierra, Phillips Sabrina, Ryan Christopher M, Sanford R Lea, Almqvist Jonas, Tran Kevin, Chew Thomas A, Zachariae Ulrich, Andersen Olaf S, Whitelegge Julian, Matulef Kimberly, Du Bois Justin, Maduke Merritt C
Abstract excerpt
The lack of small-molecule inhibitors for anion-selective transporters and channels has impeded our understanding of the complex mechanisms that underlie ion passage. The ubiquitous CLC "Chloride Channel" family represents a unique target for biophysical and biochemical studies because its distinctive protein fold supports both passive chloride channels and secondary-active chloride-proton transporters. Here, we...
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