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Article

ClC-1 chloride channels: state-of-the-art research and future challenges

27 Apr 2015

Abstract excerpt

The voltage-dependent ClC-1 chloride channel belongs to the CLC channel/transporter family. It is a homodimer comprising two individual pores which can operate independently or simultaneously according to two gating modes, the fast and the slow gate of the channel. ClC-1 is preferentially expressed in the skeletal muscle fibers where the presence of an efficient Cl(-) homeostasis is crucial for the correct...

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PMID: 25964741
DOI: 10.3389/fncel.2015.00156

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